Analysis of smooth muscle function in IRAG knockout mice
نویسندگان
چکیده
منابع مشابه
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15 صفحه اولVascular and renal function of cGMP signalling
Results For the functional analysis of cGMP signalling, transgenic murine mutants were used. cGKI signalling pathways include interaction of the cGKIb-isozyme with the inositol 1,4,5-trisphosphate receptor I (IP3RI) associated protein cGMP kinase substrate (IRAG). NO/cGMP and ANP/cGMP-dependent relaxation of aortic smooth muscle was strongly affected in IRAG-deficient mice. NO/ ANP-dependent in...
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AIMS Nitric oxide (NO) and atrial natriuretic peptide (ANP) signalling via cGMP controls smooth muscle tone. One important signalling pathway of cGMP-dependent protein kinase type I (cGKI) is mediated by IRAG (IP(3) receptor associated cGKI substrate) which is highly expressed in smooth muscle tissues. To elucidate the role of IRAG for NO- and ANP-mediated smooth muscle tone regulation, cGKI lo...
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ژورنال
عنوان ژورنال: BMC Pharmacology
سال: 2007
ISSN: 1471-2210
DOI: 10.1186/1471-2210-7-s1-p14